Please join the third Innovations in Imaging for Life Sciences Symposium at the University of Washington on June 20, 2018. The talks will focus on advances in imaging from atomic to tissue scales, including cryo-electron microscopy and volume scope imaging.
PrimeNano will give a talk on the method May 1st from 10:00 am – 11:30 am in MolES 215. They will then provide demos on the technique using our AFM Dimension Icon that afternoon and the next day.
Speaker Bio: Oskar Amster, M.S. (Sr. Dir. Marketing of PrimeNano, Inc)
Mr. Amster has a background in Physics and Materials engineering with a focus on microelectronics processing. He has 20 years experience working with analytical instruments and metrology tools. His background is in applications development, strategic marketing, and product development. He has extensive experience working in Atomic Force Microscopy, Stylus Profilers, and Optical Profiler instruments. Prior to joining PrimeNano, Inc, Oskar was at KLA-Tencor and also held positions at several start-ups as well as mature instrument companies. He holds an MS in Materials Engineering and BS in Physics from Cal Poly San Luis Obispo.
Body-on-a-Chip: an application of three-dimensional microstructuring techniques
Yoshikazu HIRAI
Department of Micro Engineering, Kyoto University, JAPAN
E-mail: hirai@me.kyoto-u.ac.jp
http://www.nms.me.kyoto-u.ac.jp/en/member/hirai/
NanoES 291
Abstract
This presentation introduces three-dimensional (3-D) microstructuring methods based on optical lithography and addresses one of their application for developing “Body-on-a-Chip.” In vitro cell-based assay with human cells is getting attention since the accuracy of preclinical predictions of drug responses should be improved to reducing costly failures in clinical trials. In order to generate reliable predictions, we have developed a micro-engineered biomimetic systems “Body-on-a-Chip,” to investigate the effects of drugs/metabolites on multi organs by assembling a closed-loop medium circulation system on one microfluidic device. For 3-D polymeric sensor/actuator device fabrication, an advanced 3-D lithography with the process optimization was applied to improve device performances. Our Body-on-a-Chip was successfully applied to evaluate the effect of an anti-cancer drug (doxorubicin) on cell survival of human heart and liver cells.
Biography
Yoshikazu Hirai received the B.S. and M.S. degrees from Ritsumeikan University, Japan, in 2002 and 2004, respectively, and the Ph.D. degree from Kyoto University, Japan, in 2007, all in mechanical engineering. He was a Post-doctoral Researcher with the Graduate School of Engineering, Kyoto University. In 2009, he joined the Advanced Biomedical Engineering Research Unit, Kyoto University. Since 2013, he has been an Assistant Professor with the Department of Micro Engineering, Kyoto University. Dr. Hirai was a recipient of the Outstanding Reviewer Award in 2016 (Journal of Micromechanics and Microengineering, IoP) and the Institute of Electrical Engineers of Japan (IEEJ) Distinguished Paper Award in 2017. His current research interests include (1) Fabrication and packaging technologies for MEMS, (2) Optical lithography for 3D microstructuring, (3) Atomic sensor device (e.g., CSAC: Chip Scale Atomic Clock, CSAM: Chip Scale Atomic Magnetometer), and (4) Microfluidic system/device for biomedical applications.
NanoES is one of 16 primary sites in the National Nanotechnology Coordinated Infrastructure (NNCI). Learn more about what NNCI is and their goals for nanotechnology in this promotional video.
The team behind A-Alpha Bio, including David Younger, a postdoc in the lab of Eric Klavins and A-Alpha Bio CEO, won the $15,000 grand prize at the 2018 Hollomon Health Innovation Challenge.
Metasurfaces are surfaces composed of sub-wavelength elements that offer an unprecedented way to manipulate light. In this talk I will first describe my work from Duke University on colloidal metasurfaces, which act as unique “paints” that can manipulate the appearance of objects at various spectral bands. Then I will describe how metasurfaces can be made dynamic, with one of the most exciting applications being spatial light modulation for imaging. The most exciting of these imaging applications is lidar for self-driving cars, which my company, Holosense, is currently developing.
Gleb M. Akselrod is the CTO and co-founder of Holosense, which is a venture-backed company in Seattle developing high-performance solid-state lidar based on metasurface technology. Previously he was the Director for Optical Technologies at Intellectual Ventures in Bellevue, WA, where he led a program on the commercialization of optical metamaterial and nanophotonic technologies. Before that he was a postdoctoral fellow in the Center for Metamaterials and Integrated Plasmonics at Duke University, where his work focused on plasmonic nanoantennas and metasurfaces. He completed his PhD in 2013 at MIT, where he studied the transport and coherence of excitons in nanostructured materials.
Interactions between light and matter lie at the heart of optical communication and information processing. Nanophotonic devices enhance light-matter interactions by confining photons to small mode volumes, enabling devices to operate at significantly lower energies. In the strong coupling regime these interactions are sufficiently large to generate a nonlinear response with a single photon, an essential component for quantum information processing applications. In this talk I will describe our effort to couple spin to light using nanophotonics. I will discuss an experimental demonstration of a quantum transistor, a fundamental building block for quantum computers and quantum networks, using a single electron spin that strongly interact with light through a nanophotonic cavity. This device enables the spin to switch a single photon, and a single photon to flip the spin. I will discuss how the nanophotonic transistor can realize high fidelity all-optical spin readout, as well as a single photon transistor where one control photon can switch many signal photons. Finally, I will describe our recent effort to extend our results into the telecommunication wavelengths, and to integrate multiple devices on a chip to assemble integrated quantum photonic circuits.
Please join the Electrical Engineering Department for the 2017-18 Research Colloquium Series on Tuesday mornings, featuring experts who discuss current issues in the electrical engineering field. Talks are open to both students and the public. Live streaming is available for most talks.
The Seattle Daily Journal of Commerce (DJC) has selected 12 finalists including the Nanoengineering & Sciences Building for the 2017 Building of the Year award. Cast your vote for NanoES here!
The University of Washington has launched a new institute aimed at accelerating research at the nanoscale: the Institute for Nano-Engineered Systems, or NanoES. Housed in a new, multimillion-dollar facility on the UW’s Seattle campus, the institute will pursue impactful advancements in a variety of disciplines — including energy, materials science, computation and medicine. Yet these advancements will be at a technological scale a thousand times smaller than the width of a human hair.
The institute was launched at a reception Dec. 4 at its headquarters in the $87.8-million Nano Engineering and Sciences Building. During the event, speakers including UW officials and NanoES partners celebrated the NanoES mission to capitalize on the university’s strong record of research at the nanoscale and engage partners in industry at the onset of new projects.
The vision of NanoES, which is part of the UW’s College of Engineering, is to act as a magnet for researchers in nanoscale science and engineering, with a focus on enabling industry partnership and entrepreneurship at the earliest stages of research projects. According to Karl Böhringer, director of the NanoES and a UW professor of electrical engineering and bioengineering, this unique approach will hasten the development of solutions to the field’s most pressing challenges: the manufacturing of scalable, high-yield nano-engineered systems for applications in information processing, energy, health and interconnected life.
“The University of Washington is well known for its expertise in nanoscale materials, processing, physics and biology — as well as its cutting-edge nanofabrication, characterization and testing facilities,” said Böhringer, who stepped down as director of the UW-based Washington Nanofabrication Facility to lead the NanoES. “NanoES will build on these strengths, bringing together people, tools and opportunities to develop nanoscale devices and systems.”
The centerpiece of the NanoES is its headquarters, the Nano Engineering and Sciences Building. The building houses 90,300 square feet of research and learning space, and was funded largely by the College of Engineering and Sound Transit. It contains an active learning classroom, a teaching laboratory and a 3,000-square-foot common area designed expressly to promote the sharing and exchanging of ideas. The remainder includes “incubator-style” office space and more than 40,000 square feet of flexible multipurpose laboratory and instrumentation space. The building’s location and design elements are intended to limit vibrations and electromagnetic interference so it can house sensitive experiments.
NanoES will house research in nanotechnology fields that hold promise for high impact, such as:
Augmented humanity, which includes technology to both aid and replace human capability in a way that joins user and machine as one – and foresees portable, wearable, implantable and networked technology for applications such as personalized medical care, among others.
Integrated photonics, which ranges from single-photon sensors for health care diagnostic tests to large-scale, integrated networks of photonic devices.
Scalable nanomanufacturing, which aims to develop low-cost, high-volume manufacturing processes. These would translate device prototypes constructed in research laboratories into system- and network-level nanomanufacturing methods for applications ranging from the 3-D printing of cell and tissue scaffolds to ultrathin solar cells.
Collaborations with other UW-based institutions will provide additional resources for the NanoES. Endeavors in scalable nanomanufacturing, for example, will rely on the roll-to-roll processing facility at the UW Clean Energy Institute‘s Washington Clean Energy Testbeds or on advanced surface characterization capabilities at the Molecular Analysis Facility. In addition, the Washington Nanofabrication Facility recently completed a three-year, $37 million upgrade to raise it to an ISO Class 5 nanofabrication facility.
UW faculty and outside collaborators will build new research programs in the Nano Engineering and Sciences Building. Eric Klavins, a UW professor of electrical engineering, recently moved part of his synthetic biology research team to the building, adjacent to his collaborators in the Molecular Engineering & Sciences Institute and the Institute for Protein Design.
“We are extremely excited about the interdisciplinary and collaborative potential of the new space,” said Klavins.
The NanoES also has already produced its first spin-out company, Tunoptix, which was co-founded by Böhringer and recently received startup funding from IP Group, a U.K.-based venture capital firm.
“IP Group is very excited to work with the University of Washington,” said Nena Golubovic, physical sciences director for IP Group. “We are looking forward to the new collaborations and developments in science and technology that will grow from this new partnership.”
“We are eager to work with our partners at the IP Group to bring our technology to the market, and we appreciate their vision and investment in the NanoES Integrated Photonics Initiative,” said Tunoptix entrepreneurial lead Mike Robinson. “NanoES was the ideal environment in which to start our company.”
The NanoES leaders hope to forge similar partnerships with researchers, investors and industry leaders to develop technologies for portable, wearable, implantable and networked nanotechnologies for personalized medical care, a more efficient interconnected life and interconnected mobility. In addition to expertise, personnel and state-of-the-art research space and equipment, the NanoES will provide training, research support and key connections to capital and corporate partners.
“We believe this unique approach is the best way to drive innovations from idea to fabrication to scale-up and testing,” said Böhringer. “Some of the most promising solutions to these huge challenges are rooted in nanotechnology.”
The NanoES is supported by funds from the College of Engineering and the National Science Foundation, as well as capital investments from investors and industry partners.